The effects of an estrogen and glycolic acid cream on the facial skin of postmenopausal women: a randomized histologic study

Study Design

Subject Type

Human

Trial Design

Double-Blind, Randomised, Controlled

Trial Duration

168 days

Participants

65 (54 completed)

Age Range

39-83 years

Efficacy

Intervention(s)			Outcome		Method		Effect	Description
Estradiol + Glycolic Acid			Skin Thickness		Micrometer		🠩	Sign in to read for free
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Glycolic Acid			Skin Thickness		Micrometer		🠩	Sign in to read for free
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Estradiol			Skin Thickness		Micrometer		🠩	Sign in to read for free
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Mechanisms

Intervention(s)			Outcome		Method		Effect	Description
Estradiol			Blood Vessels		Histology		–	Sign in to read for free
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Glycolic Acid			Blood Vessels		Histology		–	Sign in to read for free
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Estradiol			Blood Vessels		Histology		🠩	Sign in to read for free
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Glycolic Acid			Collagen		Histology		–	Sign in to read for free
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Estradiol			Collagen		Histology		–	Sign in to read for free
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Estradiol + Glycolic Acid			Collagen		Histology		⇧	Sign in to read for free
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Glycolic Acid			Elastic Fibres		Histology		⇧	Sign in to read for free
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Estradiol			Elastic Fibres		Histology		⇧	Sign in to read for free
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Estradiol + Glycolic Acid			Elastic Fibres		Histology		⇧	Sign in to read for free
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Estradiol + Glycolic Acid			Rete Pegs		Micrometer		🠩	Sign in to read for free
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Estradiol			Rete Pegs		Micrometer		🠩	Sign in to read for free
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Glycolic Acid			Rete Pegs		Micrometer		🠩	Sign in to read for free
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Side Effects

Intervention(s)			Outcome		Effect	Description
Glycolic Acid			Hyperpigmentation		–	Sign in to read for free
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Estradiol			Hyperpigmentation		–	Sign in to read for free
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Estradiol + Glycolic Acid			Hyperpigmentation		–	Sign in to read for free
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Glycolic Acid			Inflammation		–	Sign in to read for free
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Estradiol			Inflammation		–	Sign in to read for free
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Estradiol + Glycolic Acid			Inflammation		–	Sign in to read for free
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Estradiol + Glycolic Acid			Skin Sensitivity		⇧	Sign in to read for free
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Estradiol			Skin Sensitivity		⇧	Sign in to read for free
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Glycolic Acid			Skin Sensitivity		⇧	Sign in to read for free
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Study Summary

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