A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen

Study Design

Subject Type

Human

Trial Design

Single-Blind, Randomised, Controlled

Trial Duration

168 days

Participants

196 (190 completed)

Age Range

40-65 years

Efficacy

Intervention(s)			Outcome		Method		Effect	Description
Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment			Skin Barrier Function		Vapometer		🠩	Sign in to read for free
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Tretinoin			Skin Barrier Function		Vapometer		🠫	Sign in to read for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment			Skin Smoothness		Self-assessment		🠩	Sign in to read for free
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Tretinoin			Skin Smoothness		Self-assessment		🠩	Sign in to read for free
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Tretinoin			Wrinkles		VISIA		🠫	Sign in to read for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment			Wrinkles		VISIA		🠫	Sign in to read for free
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Mechanisms

Intervention(s)			Outcome		Method		Effect	Description
Tretinoin			Human Serum Albumin		Immunoassay		🠩	Sign in to read for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment			Human Serum Albumin		Immunoassay		🠫	Sign in to read for free
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Tretinoin			Involucrin		Immunoassay		🠩	Sign in to read for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment			Involucrin		Immunoassay		🠫	Sign in to read for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment			Keratin		Immunoassay		🠩	Sign in to read for free
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Tretinoin			Keratin		Immunoassay		🠫	Sign in to read for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment			Soluble Protein		Immunoassay		🠫	Sign in to read for free
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Tretinoin			Soluble Protein		Immunoassay		🠩	Sign in to read for free
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Side Effects

Intervention(s)			Outcome		Effect	Description
Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment			Skin Hydration		–	Sign in to read for free
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Tretinoin			Skin Hydration		⇩	Sign in to read for free
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Tretinoin			Skin Redness		⇧	Sign in to read for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment			Skin Redness		⇧	Sign in to read for free
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Study Summary

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